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Loco regional hyperthermia target specific organs or biological tissues who makes defaults Until recently, heat shock proteins (also known as heat stress proteins) have mostly been regarded as intracellular molecules that mediate a range of essential housekeeping and cytoprotective functions. However, interest in their role as intercellular signalling molecules has been fuelled by the observations that these molecules can be released and are present in the extracellular environment under physiological conditions. They can elicit cytokine production by, and adhesion molecule expression of, a range of cell types, and they can deliver maturation signals and peptides to antigen presenting cells through receptor-mediated interactions. These functions suggest that heat shock proteins could be immunoregulatory agents with potent and widely-applicable therapeutic uses. Furthermore, the induction of self heat shock protein immune reactivity can attenuate autoimmunity and delay transplant rejection, and heat shock proteins derived from tumours and pathogens can elicit specific, protective immunity. This review will focus on this rapidly evolving area of heat shock protein biology.
CardioWave Equipment
First Equipment Worldwide for Heart Failures.
Heat shock proteins (HSPs), a family of proteins that support cellular proteostasis and perform a protective function under various stress conditions, such as high temperature, intoxication, inflammation, or tissue hypoxia, constitute a promising group of possible biochemical markers for obesity and cardiovascular diseases. HSP27 is involved in essential cellular processes occurring in conditions of obesity and its cardiometabolic complications; it has protective properties, and its secretion may indicate a cellular response to stress. HSP40 plays a controversial role in the pathogenesis of obesity. HSP60 is involved in various pathological processes of the cardiovascular, immune, excretory, and nervous systems and is associated with obesity and concomitant diseases. The hypersecretion of HSP60 is associated with poor prognosis; hence, this protein may become a target for further research on obesity and its cardiovascular complications. According to most studies, intracellular HSP70 is an obesity-promoting factor, whereas extracellular HSP70 exhibited inconsistent dynamics across different patient groups and diagnoses. HSPs are involved in the pathogenesis of cardiovascular pathology. However, in the context of cardiovascular and metabolic pathology.
Diabetes Equipment
First Equipment Worldwide for Diabetes.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by sustained hyperglycemia caused by impaired insulin signaling and secretion. Metabolic stress, caused by an inappropriate diet, is one of the major hallmarks provoking inflammation, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Heat shock proteins (HSPs) are a group of highly conserved proteins that have a crucial role in chaperoning damaged and misfolded proteins to avoid disruption of cellular homeostasis under stress conditions. To do this, HSPs interact with diverse intra-and extracellular pathways among which are the insulin signaling, insulin secretion, and apoptosis pathways. Therefore, HSP dysfunction, e.g. HSP70, may lead to disruption of the pathways responsible for insulin secretion and uptake. Consistently, the altered expression of other HSPs and genetic polymorphisms in HSP-producing genes in diabetic subjects has made HSPs hot research in T2DM. This paper provides a comprehensive overview of the role of different HSPs in T2DM pathogenesis, affected cellular pathways, and the potential therapeutic strategies targeting HSPs in T2DM.
Overview Indications
Overview of indications treated with AEG Hyperthermia equipments
Oncology Cabinet Hyperthermia
Hyperthermia Equipment for use in Radiotherapy centre.
Hyperthermia Enhances Radiation-Induced Cell Killing
Hyperthermia is used to treat external tumors such as sarcoma [83], cervix [84] or with surgically accessible tumors such as prostate [85] and liver [86]. Agarwal and coworkers used multiple approaches to determine the effect of telomerase inactivation on heat- induced cell killing because telomerase activation has been linked with extension of cell life span. Hyperthermia is a potent radiosensitizer that has been under clinical investigation as a means to improve the response to ionizing radiation (IR)–based cancer treatments, and acts to improve the local tumor control.
I-Wave Monitoring System Hyperthermia
Chemotherapy oncology
Urology BPH
Neuro Diseases
Hyperthermia is one of the most promising new multidisciplinary approaches to cancer therapy. The rationale for raising temperature in tumor tissue is based on a direct cell-killing effect at temperatures above 41-42°C and a synergistic interaction between heat and radiation as well as various antineoplastic agents. The thermal dose-response depends also on microenvironmental factors such as pH, and pO2 in the tumor tissue. Depending on the physical characteristics of the energy field applied, also other mechanisms of tumor destruction or growth retardation may be relevant. Tissue-specific electromagnetic interactions may be possible, depending on frequency and applicator technique used, due to inhomogeneities in the relative dielectric permittivity, relative magnetic permeability, specific conductivity, and ion distribution in cancer tissue compared to normal tissue.
The effects of hyperthermia on the host and cancer tissue are pleiotropic and depend mainly on the temperature and the physical techniques applied. The biological and molecular mechanisms of these effects are changes in the membrane,1-5 the cytoskeleton, the ion-gradient and membrane potential,6-11 synthesis of macromolecules and DNA-replication,12-14 intra- and extracellular pH (acidosis15-17) and decrease in intracellular ATP.17 Genes can be up-regulated or down-regulated by heat, for example the heat-shock proteins (HSP).18
Synergistic effects by interactions with antineoplastic agents, radiation and heat can be several powers of ten even at moderate temperatures. In addition, reduced chemotherapy resistancy, possibly due to increased tissue penetration, increased membrane permeability, and activated metabolism, has been observed.
Immunological effects of hyperthermia may play an additional role in cancer therapy such as immunological effects on cellular effector cells (emigration, migration and activation), induction of cytokines, chemokines and heat shock proteins (chaperones), and modulation of cell adhesion molecules. The induction of heat-shock proteins might increase specific immune responses to cancer cells.